Protecting our minds and bodies is something that we as humans have done for millennium. Realizing our overall health is pivotal for our survival is just step one. The next step to follow is that our minds start to become the forefront of understanding. After all, it is what essentially send the correct information throughout our bodies. So why haven’t we been taking care of it to the correct capacity and how do we start? With the help of a nootropic called NMN.
What is NMN?
NMN or nicotinamide mononucleotide is a nucleotide that comes from ribose and nicotinamide. Its naturally made from B vitamins within the body. Much like another substance called nicotinamide riboside, human enzymes use nicotinamide mononucleotide to create nicotinamide adenine dinucleotide. Because of the mechanism of how nicotinamide mononucleotide works, it has been studied in animals on several occasions as a neuroprotective agent as well as a possibility for anti-aging.
Benefits of NMN
When it comes to signs of aging, an adjustment to cerebral blood flow by experiencing neurovascular coupling is important for good cognitive function. Experiencing a decrease in NAD+ may be a contributing cause to decreased cognitive function. In order to find out if this is the case, researcher are conducting experiments using NMN to see if restoring NAD+ would benefit neurovascular coupling in aging.
Twenty four month old mice received the treatment of nicotinamide mononucleotide for a total of two weeks at 500mg/kg of their bodyweight. NVC or neurovascular coupling before any administrations of the nootropic had been significantly impaired in the aged mice. However, after the administration of the nootropic, an increase of endothelial NO mediated vasodilation occurred. This means that spatial working memory and gait coordination were improved significantly in the mice given the supplement. At the conclusion of the research it was found that NMN is a possibility for preventative and therapeutic potential in regards to NAD+ as it can be used with patients at risk for vascular cognitive impairment.
Muscle & Strength
When it comes to aging, our muscles tend to experience a decline for several reasons. Because of this, it has become ever apparent to researchers and medical professionals to find a viable way to improve the physiology of humans so that the decline happens at a slower rate.
A twelve month long study took place using NMN to see if an increase in NAD+ could mitigate the effects of muscle aging. The mice involved took 300mg/kg of body weight. Nicotinamide mononucleotide increased rapidly from about 2.5 minutes after administration to around 10 minutes. Then at the fifteen minute mark, levels reduced back to their original measurement. This means that the nootropic was digested fairly quicky by the gut. Then from the fifteen to thirty minute mark there was more of a steady increase. At the end of the experiment, nicotinamide mononucleotide was found to be able to prevent age associated gene expression for certain metabolic organs.
Are There Side Effects?
Most research uses common rodent species and there have been no negative side effects. In contrast it has actually been proven to positively impact brain and liver function as well as bone structure, heart health, and the metabolism. For human studies with nicotinamide mononucleotide there have luckily enough been no real safety concerns either when it comes to the correct doses. There was no change in heart rate, blood pressure, or blood oxygen levels at doses tested.
Dosage of NMN
As mentioned above, when using NMN correctly, there are literally no side effects. But of course, it is important to know the correct doses. A single oral dose between 100mg and 500mg is safe according to several researchers. Not much information is available doses higher than 500mg. That being said, since we know there are no side effects for the above doses, this is what is commonly recommended since it does what it needs to do.
When it comes to overall health, the nootropic NMN can cover several bases. Not only is it neuroprotective, but it also helps with other areas of the body that need the extra help. So, what are you waiting for? Why not get your NMN now?
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